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pentobarbital will reduce the extent or impact of parecoxib by affecting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Watch.pentobarbital decreases consequences of sufentanil SL by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of CYP3A4 inducers may well lower sufentanil levels and